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Figure 4 Inflammatory stressors (e.g., IL-1β, TNF-α) and mechanical injury disrupt mitophagy through multiple signaling nodes, among which dysfunction of the PTEN-induced putative kinase 1 (PINK1)–Parkin RBR E3 ubiquitin protein ligase (Parkin)pathway is particularly prominent

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Similarly, neuroserpin gene therapy has demonstrated a protective role against oxidative stress by inhibiting RGC apoptosis and promoting functional preservation in glaucoma models (293)